Electronic Class II Controlled Substance Ordering

Class II controlled substances can now be ordered through our secure electronic Controlled Substances Ordering System (CSOS) without the supporting paper DEA Form 222!


CSOS was developed by the DEA for the electronic transmission of Class II controlled substances orders. It is the only allowance for electronic ordering of Class II controlled substances.

Using the DEA’s CSOS program to order Class II controlled substances provides you with the following benefits:

  • Significant reduction in the number of ordering errors
  • Ability to include more line items on a single order
  • Faster transaction times
  • Lower costs due to order accuracy and decreased paperwork


The DEA’s CSOS program requires that each individual purchaser enroll with the DEA to acquire a CSOS digital certificate before placing an electronic order for Class II Controlled Substances. Each digital certificate contains identification information specific to each individual subscriber and his/her associated DEA registration. Multiple digital certificates must be requested for applicants requiring the ability to sign electronic Class II controlled substance orders for multiple DEA Registration numbers.

Enroll in the DEA’s CSOS Program


Once you have successfully installed the CSOS digital certificate on your computer, please contact Customer Service to enroll in the Bound Tree e222 program. After receiving your login information from Customer Service, you may start ordering Class II Controlled Substances from Bound Tree Medical’s secure electronic Controlled Substances Ordering System (e222.boundtree.com).

Please Note:

  • If this is your first time placing a pharmaceutical order with Bound Tree Medical you will also need to complete a License Authorization Form (LAF).
  • Controlled Substance orders are subject to a handling fee of $11.95.

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e222 Enrollment Process Submit the DEA CSOS Application Contact Bound Tree Customer Service Start placing e222 orders Enter receiving information in e222 website Perform digital certificate and email test

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Enrollment and ordering process demonstrations (VIDEOS)

Frequently Asked Questions (FAQs) (PDF)

Choosing your CSOS application type (PDF)

Comprehensive Support Document for CSOS Subscribers (PDF)

Learn more about the Bound Tree Pharmaceutical Advantage